Mitelman Database Release Notes

To search this database hosted by the ISB-CGC, please visit Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

For more detailed information about the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer, see Mitelman Database.

January 16, 2024

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Additionally, there was a bug fix related to the result download button.

Updated totals

  • Total number of cases 77,532

  • Total number of unique gene fusions 33,802

  • Total number of genes involved 14,051

October 16, 2023

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

More than 200 new cases were added, in addition to many new gene fusions. A number of genes that were reclassified as pseudogenes have also been removed, resulting in a small net gain in gene and fusion counts.

Updated totals

  • Total number of cases 77,061

  • Total number of unique gene fusions 33,711

  • Total number of genes involved 14,046

August 3, 2023

Added missing data, plus some additional new cases.

Updated totals

  • Total number of cases 76,835

  • Total number of unique gene fusions 33,710

  • Total number of genes involved 14,059

July 17, 2023

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 76,534

  • Total number of unique gene fusions 33,671

  • Total number of genes involved 14,056

April 17, 2023

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 76,239

  • Total number of unique gene fusions 33,968

  • Total number of genes involved 14,097

January 19, 2023

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 75,312

  • Total number of unique gene fusions 33,885

  • Total number of genes involved 14,091

October 17, 2022

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 74,420

  • Total number of unique gene fusions 33,621

  • Total number of genes involved 14,068

July 27, 2022

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 73,930

  • Total number of unique gene fusions 33,457

  • Total number of genes involved 14,061

June 6, 2022

Enhancements and New Features

Mitelman Database Now Includes Genomic Coordinates

Until June 2022, the resulting genetic location information retrieved from the database was only displayed in karyotypes. Now, genomic coordinates are also displayed. Thanks to procedures incorporated from the web-based tool CytoConverter, karyotypes are converted to genomic coordinates and can be optionally viewed by the Mitelman Database user.

The user has the option of viewing the genomic coordinate information for either individual karyotypes or for multiple karyotypes in a search result. For individual karyotypes, the corresponding chromosome and its start and end position are given. In addition, the type of imbalance (gain or loss) is noted. For multiple karyotypes in the search results, net imbalances across the selected group are displayed in chart, ideogram or tabular format; information includes the chromosome affected, start and end positions, and whether the segment has been lost or gained.

April 18, 2022

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 72,718

  • Total number of unique gene fusions 32,962

  • Total number of genes involved 14,016

January 18, 2022

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 72,421

  • Total number of unique gene fusions 32,855

  • Total number of genes involved 14,022

Enhancements and New Features

According to the recent recommendations of The Hugo Genome Nomenclature Committee (HGNC), the designations of all fusion genes have been changed from forward slash (/) to double colon (::). This affects the searches: “Gene Fusions”, Clinical Associations”, and “Recurrent Chromosome Aberrations”.

October 15, 2021

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 72,105

  • Total number of unique gene fusions 32,795

  • Total number of genes involved 14,023

Enhancements and New Features

  • Removed the size limit on the search results: User can perform blank searches to retrieve the full data.

  • View SQL Statements: User can view and utilize the new SQL statement that was used to perform the search.

July 15, 2021

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 71,734

  • Total number of unique gene fusions 32,721

  • Total number of genes involved 14,019

Enhancements

Security enhancement (including Data Tables package version update)

April 15, 2021

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 71,298

  • Total number of unique gene fusions 32,677

  • Total number of genes involved 14,020

Bug Fixes

Gene Fusion Search failed to return gene fusion results if searched by gene names with a hyphen (‘-’) in it (e.g. ARPC4-TTLL3). This has been fixed.

January 15, 2021

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 71,149

  • Total number of unique gene fusions 32,618

  • Total number of genes involved 14,016

October 26, 2020

Bug Fixes

Cases Cytogenetics Searcher: Using ‘Sole Abnormality’ flag with a ‘Breakpoint’ entry will now search cases with karyotypes of sole abnormality with the specified breakpoint.

October 15, 2020

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 70,818

  • Total number of unique gene fusions 32,578

  • Total number of genes involved 14,014

July 15, 2020

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 70,469

  • Total number of unique gene fusions 32,551

  • Total number of genes involved 14,014

April 15, 2020

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer quarterly update.

Updated totals

  • Total number of cases 70,236

  • Total number of unique gene fusions 31,626

  • Total number of genes involved 13,913

Other changes

  • New Mitelman Database Logo

August 27, 2019

Initial Release

  • Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer released on the ISB-CGC platform.

The following searches are available:

  • Cases Cytogenetics Searcher

  • Gene Fusions Searcher

  • Clinical Associations Searcher

  • Recurrent Chromosome Aberrations Searcher

  • References Searcher


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