Data Security and Access Overview¶
Understanding Data Security¶
Much of the low-level TCGA and TARGET data (including DNA and RNA reads, and SNP CEL files, for example) are classified as “controlled access data” and are under the control of the dbGaP Data Access Committee (DAC).
Investigator(s) requesting to receive Genomic data in accordance with the NIH Genomic Data Sharing Policy are required to submit:
- a data access request (DAR)
- a research use statement (RUS)
Note: Requesters and institutional signing officials (SO) must have NIH eRA user IDs to begin this process. Visit the electronic Research Administration (eRA) for more information on registering for an NIH eRA account. NIH staff may utilize their NIH login. (See the dbGaP Data Access Request Portal for additional instructions.)
Additionally, they must:
- Submit a Data Use Certification (DUC) co-signed by the designated Institutional Official(s) at their sponsoring institution
- Protect data confidentiality (any data which has been designated “controlled” must be protected accordingly, unless prior release authorization is obtained from an NCI data custodian)
- Ensure that appropriate data security measures are in place
In the context of Google Cloud Platform (GCP) projects, it is important to realize that all members of a GCP project have (at least) read access to all data stored within that project, as well as to all virtual machines, boot disks, and persistent disks attached to that project. Therefore, if a PI establishes a GCP project (project-A) for the purposes of analyzing controlled data (eg performing mutation analysis on TCGA sequence data), then all members of project-A must be authorized to view controlled data. The outputs of certain analyses performed on controlled data, if they are summary in nature, may no longer be controlled data and could be copied to a second GCP project (project-B) for further downstream analyses by researchers who are not authorized to view controlled data. Researchers who are not authorized to view controlled data could be made members of project-B, while users who are authorized could be members of both project-A and project-B.
Note: The PI and the PI’s institution are responsible for and will be held accountable for ensuring the security of controlled data, not the cloud service provider. The Google Cloud Platform has been certified as FedRAMP compliant which means that it has been independently assessed and shown to meet all necessary FedRAMP security controls. This provides the assurance that the data security and access control mechanisms implemented by the Google Cloud Platform and made available to end users are sufficient to safeguard the data. However, it remains the PI’s responsibility to ensure that these access control mechanisms are used appropriately and effectively within the context of the PI’s GCP project.
You should think about securing controlled data within the context of your GCP project in the same way that you would think about securing controlled data that you might download to a file server or compute cluster at your own institution. Your responsibilities regarding the appropriate use of the data are the same in a cloud environment. For more information, please refer to the NIH Security Best Practices for Controlled-Access Data.
“The Investigator and their associated institution assume the responsibility for the security of the dbGaP data. As such, NIH has tried to provide as much information as possible for PIs, institutional signing officials (SOs) and the IT staff who will be supporting these projects, to make sure they understand their responsibilities.” (Ref: The Cloud, dbGaP and the NIH blog post 03.27.2015)
Understanding Data Access¶
- Public Data Sometimes the word “public” is misinterpreted as meaning “open”. All of the TCGA data is public data, and much of it is open, meaning that it is accessible and available to all users; while some low-level TCGA data is controlled and restricted to authorized users.
- Open-Access Data Depending on how you categorize the data, most of the TCGA data is open-access data. This includes all de-identified clinical and biospecimen data, as well as all Level-3 molecular data including gene expression data, DNA methylation data, DNA copy-number data, protein expression data, somatic mutation calls, etc.
- Controlled-Access Data All low-level sequence data (both DNA-seq and RNA-seq), the raw SNP array data (CEL files), germline mutation calls, and a small amount of other data are treated as controlled data and require that a user is properly authenticated and have dbGaP authorization prior to accessing these data.
In the earlier days of the TCGA data, although the data was made public as quickly as possible, it was generally under embargo for some period of time, to allow the TCGA analysis working groups to produce the initial “marker paper” for each tumor type. Now that the TCGA project is nearing completion, none of the TCGA data is under embargo anymore, but we still recommend that you review the TCGA Publication Guidelines.