MMRF Data Set¶
About the Multiple Myeloma Research Foundation¶
The Multiple Myeloma Research Foundation (MMRF) seeks to provide resources and research for patients with multiple myeloma. MMRF began a ten-year study to track new Multiple Myeloma patients to create a rich data set which was led by researchers from the Dana Farber Cancer Institute, Celgene Corp., and the University of Arkansas for Medical Sciences. This trial was named CoMMpass.
About the Multiple Myeloma Research Foundation Data¶
The CoMMpass trial is a longitudinal observation study of 1000 newly diagnosed myeloma patients receiving various standard approved treatments. This trial aims to collect tissue samples and genetic information along with quality of life, disease, and clinical outcomes. CoMMpass data consists of 995 cases with RNA, whole-exome, and whole-genome sequencing data. The NCI GDC houses all the molecular characterization data with over 10,918 VCF, 6,577 BAM, 2,577 TXT, and 1718 TSV files in around 206.63 TB of data. The Project ID in the GDC Data Portal is MMRF-COMMPASS.
For more information on the MMRF data, please refer to these sites:
Accessing Multiple Myeloma Research Foundation Data on the Cloud¶
Besides accessing the files on the GDC Data Portal, you can also access them from the GDC Google Cloud Storage Bucket, which means that you don’t need to download them to perform analysis. ISB-CGC stores the cloud file locations in tables in the
isb-cgc-bq.GDC_case_file_metadata data set in BigQuery.
- To access these metadata files, go to the Google BigQuery console.
- Perform SQL queries to find the MMRF files. Here is an example:
SELECT active.*, file_gdc_url FFROM `isb-cgc-bq.GDC_case_file_metadata.fileData_active_current` as active, `isb-cgc-bq.GDC_case_file_metadata.GDCfileID_to_GCSurl_current` as GCSurl WHERE program_name = 'MMRF' AND active.file_gdc_id = GCSurl.file_gdc_id