About the Pancreas Cancer Organoid Profiling Program

The Pancreas Cancer Organoid Profiling Program is from the Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer study and contains data generated from a collection of patient-derived pancreatic normal and cancer organoids.

About the Pancreas Cancer Organoid Profiling Data Set

The data set consists of 70 cases and includes whole-genome, targeted exome, and RNA sequencing data on organoids as well as matched tumor and normal tissues. This data set is a valuable resource for pancreas cancer researchers, and those looking to compare primary tissue to organoid culture. The NCI GDC houses all the clinical, biospecimen, and molecular characterization data with over 130 VCF, 298 BAM, 165 TXT, and 110 TSV files in around 21.89 TB of data. The Project ID in the GDC Data Portal is ORGANOID-PANCREATIC.

For more information on the ORGANOID data, please refer to these sites:

Accessing Pancreas Cancer Organoid Profiling Data on the Cloud

Besides accessing the files on the GDC Data Portal, you can also access them from the GDC Google Cloud Storage Bucket, which means that you don’t need to download them to perform analysis. ISB-CGC stores the cloud file locations in tables in the isb-cgc-bq.GDC_case_file_metadata data set in BigQuery.

  • To access these metadata files, go to the Google BigQuery console.

  • Perform SQL queries to find the ORGANOID files. Here is an example:

SELECT active.*, file_gdc_url
FROM `isb-cgc-bq.GDC_case_file_metadata.fileData_active_current` as active, `isb-cgc-bq.GDC_case_file_metadata.GDCfileID_to_GCSurl_current` as GCSurl
WHERE program_name = 'ORGANOID'
AND active.file_gdc_id = GCSurl.file_gdc_id

Accessing the ORGANOID Data in Google BigQuery

ISB-CGC has ORGANOID data, such as clinical and RNA-seq, stored in Google BigQuery tables. Information about these tables can be found using the ISB-CGC BigQuery Table Search with ORGANOID selected for filter PROGRAM. To learn more about this tool, see the ISB-CGC BigQuery Table Search documentation.

The ORGANOID tables are in project isb-cgc-bq. To learn more about how to view and query tables in the Google BigQuery console, see the ISB-CGC BigQuery Tables documentation.

  • Data set isb-cgc-bq.ORGANOID contains the latest tables for each data type.

  • Data set isb-cgc-bq.ORGANOID_versioned contains previously released tables, as well as the most current table.

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