About the NCI Center for Cancer Research

The NCI Center for Cancer Research (NCICCR) conducted a study on the Genomic Variation in Diffuse Large B Cell Lymphomas (DLBCL) through an integrative analysis of genetic lesions in 574 diffuse large B cell lymphomas (DLBCL). The study investigated genomic structural variation, genetic alteration, and its effect on the development and biology of lymphomas by using high throughput sequencing, gene expression, and methylation status.

About the NCI Center for Cancer Research Data

There were around 489 cases that were phenotyped, contributing Authorized-Access, individual-level data. The Genomic Data Commons currently has around 957 controlled access BAM files available. The Project ID in the GDC Data Portal is NCICCR-DLBCL.

For more information on the NCICCR data, please refer to these sites:

Accessing the NCI Center for Cancer Research Data on the Cloud

Besides accessing the files on the GDC Data Portal, you can also access them from the GDC Google Cloud Storage Bucket, which means that you don’t need to download them to perform analysis. ISB-CGC stores the cloud file locations in tables in the isb-cgc-bq.GDC_case_file_metadata data set in BigQuery.

  • To access these metadata files, go to the Google BigQuery console.

  • Perform SQL queries to find the NCICCR files. Here is an example:

SELECT active.*, file_gdc_url
FROM `isb-cgc-bq.GDC_case_file_metadata.fileData_active_current` as active, `isb-cgc-bq.GDC_case_file_metadata.GDCfileID_to_GCSurl_current` as GCSurl
WHERE program_name = 'NCICCR'
AND active.file_gdc_id = GCSurl.file_gdc_id

Accessing the NCICCR Data in Google BigQuery

ISB-CGC has NCICCR data, such as clinical, metadata and RNA-seq stored in Google BigQuery tables. Information about these tables can be found using the ISB-CGC BigQuery Table Search with NCICCR selected for filter PROGRAM. To learn more about this tool, see the ISB-CGC BigQuery Table Search documentation.

The NCICCR tables are in project isb-cgc-bq. To learn more about how to view and query tables in the Google BigQuery console, see the ISB-CGC BigQuery Tables documentation.

  • Data set isb-cgc-bq.NCICCR contains the latest tables for each data type.

  • Data set isb-cgc-bq.NCICCR_versioned contains previously released tables, as well as the most current table.

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