About the VA Research for Precision Oncology Program

The Research for Precision Oncology Program (RePOP) is a research activity that established a cohort of Veterans diagnosed with cancer and had genomic analyses performed on their tumor tissue as part of the standard of care. All data relevant to a patient’s cancer and cancer care was collected under RePOP, including patient demographics, comorbidities, genomic analysis, treatments, medications, lab values, imaging studies, and outcomes. All RePOP participants signed/verbal informed consent and signed HIPAA authorization to have their data stored and shared from RePOP’s Precision Oncology Program Data Repository (PODR).

About the VA Research for Precision Oncology Program Data

The VARePOP data set consists of 7 cases with somatic mutation and targeted sequencing data. The Genomic Data Commons currently has controlled access BAM and VCF files. The Project ID in the GDC Data Portal is VAREPOP-APOLLO.

For more information on the VAREPOP data, please refer to these sites:

Accessing the VA Research for Precision Oncology Program on the Cloud

Besides accessing the files on the GDC Data Portal, you can also access them from the GDC Google Cloud Storage Bucket, which means that you don’t need to download them to perform analysis. ISB-CGC stores the cloud file locations in tables in the isb-cgc-bq.GDC_case_file_metadata data set in BigQuery.

  • To access these metadata files, go to the Google BigQuery console.

  • Perform SQL queries to find the VAREPOP files. Here is an example:

SELECT active.*, file_gdc_url
FROM `isb-cgc-bq.GDC_case_file_metadata.fileData_active_current` as active, `isb-cgc-bq.GDC_case_file_metadata.GDCfileID_to_GCSurl_current` as GCSurl
WHERE program_name = 'VAREPOP'
AND active.file_gdc_id = GCSurl.file_gdc_id

Accessing the VAREPOP Data in Google BigQuery

ISB-CGC has VAREPOP data, such as clinical, stored in Google BigQuery tables. Information about these tables can be found using the ISB-CGC BigQuery Table Search with VAREPOP selected for filter PROGRAM. To learn more about this tool, see the ISB-CGC BigQuery Table Search documentation.

The VAREPOP tables are in project isb-cgc-bq. To learn more about how to view and query tables in the Google BigQuery console, see the ISB-CGC BigQuery Tables documentation.

  • Data set isb-cgc-bq.VAREPOP contains the latest tables for each data type.

  • Data set isb-cgc-bq.VAREPOP_versioned contains previously released tables, as well as the most current table.

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